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As Hemmi notes: Some people will lose access. In an emailed statement to WIRED, a spokesperson for Novo Nordisk says, Moving forward, any compounder that mass produces or sells knockoff drugs is breaking the law and compromising patient safety. A spokesperson for Eli Lilly echoed that sentiment, saying via email that the FDA and a federal court have both made clear that compounders must cease production of compounded tirzepatide knockoffs. Anthony Comuzzie, CEO of the Obesity Society, recognizes that there are legitimate access issues to GLP-1 medications, but he worries that some people who have sought out compounded versions may not meet the medical definition of obesity and are using them more casually for weight loss

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Severe Gastrointestinal Symptoms : While mild to moderate nausea, vomiting, and diarrhea are common with tirzepatide, especially during dose escalation, severe or persistent symptoms warrant medical attention

What the mechanism does NOT prove: Demonstrating a pathway in cell culture or rodents does not confirm the same pathway is activated in humans at achievable tissue concentrations following subcutaneous injection

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