[1] Primary mechanisms: modulation of the nitric oxide (NO) system via upregulation of eNOS, activation of VEGFR2-Akt-eNOS signaling for angiogenesis, and enhancement of antioxidant defenses (HO-1 upregulation)
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References Jastreboff AM, et al
FIGURE 1 FIGURE 2 4 Evaluation of the efficacy and safety of tirzepatide in the treatment of type 2 diabetes and cardiovascular risk management 4.1 SURPASS-1: efficacy of tirzepatide on HbA1c and weight change The SURPASS-1 trial included 478 patients and compared the efficacy of tirzepatide at doses of 5 mg, 10 mg, and 15 mg
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Zepbound is the first and only weight-loss medication in its class: dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonists