That dual mechanism, reduced input plus increased output, explains the dramatic differences in clinical trial results
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Phase 1 studies showed linear exposure of Linafexor with dosing and no adverse effects associated with treatment
Grimm M, Han J, Weaver C, Griffin P, Schulteis CT, Dong H, Malloy J (2013) Efficacy, safety, and tolerability of exenatide once weekly in patients with type 2 diabetes mellitus: an integrated analysis of the DURATION trials
As an example, different values of the oxygen diffusion coefficient can be found in the literature 34,35 depending on the location inside the skin and on the orientation (see Table 1)