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The SURMOUNT-1 trial reported the following side effect rates among participants taking tirzepatide: Nausea: up to 20% of participants Diarrhea: approximately 16% Constipation: approximately 11% Decreased appetite: this is expected and often the desired mechanism of action Vomiting: approximately 6 to 9% Injection site reactions: mild, infrequent Most side effects peak during the first one to two weeks after each dose increase and then gradually subside as the body adapts
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