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Redox Signal 24 , 680712 (2015)

Long term secretion of Exe4 peptide in the genome-edited mice To examine the prolonged expression of Exe4 following a single genome editing procedure, we administrated HITI components, including the scExe4 donor with gRNA expression cassette and Cas9-expression DNAs, via intravenous injection of DNA-loaded LNPs into Balb/c mice (Fig