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In addition to the high discordance rates between monozygotic twins, the importance of epigenetic mechanisms is evident in the chronic relapsing nature of these diseases, and the higher incidence of MDD in women after puberty [15, 16]

M., Chen, Y., ONeill, E

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GIP Receptor Distribution: **Adipose tissue: Adipocyte metabolism, nutrient partitioning Brain: Modulates energy balance Bone: May positively influence bone metabolism Clinically, this translates into greater weight loss than GLP-1 aloneoften approaching or exceeding 20% of body weight in trials

Peptides are often biologically active as signaling molecules without requiring full protein folding