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Thiamine and its pharmacological forms, as a primary or adjunctive therapy, have been shown to improve symptoms such as nausea, constipation, dysphagia and intestinal dysmotility, in both humans and animals
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These include: Pain, redness, or swelling at the injection site Bruising or hardening of tissue (induration) Itching or warmth around the injection area Temporary discolouration of the skin These localised reactions typically resolve within 2472 hours
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(2015) demonstrated that metformin, a first-line drug for treatment of type 2 diabetes mellitus, has therapeutic effects against ALI by inhibiting p-JNK via upregulation of Gadd45