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Research in rodents indicates that apart from the activation of MMP2, the peptide might also activate fibroblasts, which produce and maintain MMP2 and other components of the extracellular matrix, such as collagen and elastin

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The cultures were then centrifuged for 10 min at 10,000 rpm, and 7.5 mL of the supernatants were transferred into new Falcon tubes

Peer review Peer review information Nature Reviews Drug Discovery thanks Robert Thorne, Richard Keep and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Cold Spring Harbor Perspectives in Biology