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The absolute risk appears to be rare based on clinical trial and post-marketing data
This contributes to the overall cardiovascular benefit demonstrated in the SELECT trial, where semaglutide reduced major adverse cardiovascular events by 20% compared to placebo
Pal J, Sanal MG, Gopal GJ
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O408-06: Safety, pharmacokinetics (PK), and florbetapir F-18 positron emission tomography (PET) after multiple dose administration of LY3002813, a -amyloid plaque-specific antibody, in Alzheimers disease
It was impressive to see that every dose of retatrutide resulted in clinically meaningful weight reduction for nearly all participants, and people with severe obesity on the highest dose lost on average 30% of their body weight over two years, lead investigator Ania Jastreboff, MD, professor of medicine and pediatrics at the Yale School of Medicine and director of the Yale Obesity Research Center, said in a press release
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