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The most frequently reported adverse effects were gastrointestinal in nature, generally mild to moderate in severity and transient, typically occurring during the dose-escalation period
Those are built through a different kind of healing
Aroda et al., 2019
Participants in these trials experienced substantial weight loss, with average reductions of 15-20% of their initial body weight
A 55% reduction of muscle glycogen consumption at 50% VO2 max and a 38% reduction at 80% VO2 max
Hence, it is necessary to identify molecularly targeted drugs under different conditions, including normal oxygen levels and hypoxia (acute and chronic), equally inhibiting the targeting molecule or the pathway, helping to ensure that clinical resistance is not just due to drugs ineffective in hypoxic cells
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