I would see the Zealand/Roche deal as much more risky and expensive relative to risk as that is for a less certain MoA (amylin) but if course much further in itsdevelopment.
Effect of Ornithine -Ketoglutarate on intestinal microbiota and serum inflammatory cytokines in dextran sulfate sodium induced colitis
Normal adjustment symptoms These are expected and typically manageable: loose stools 1 to 3 times daily during dose escalation, mild abdominal cramping before bowel movements, increased urgency (needing to go sooner than usual), softer stool consistency without other alarming features, symptoms that correlate with recent dose increases, and gradual improvement over 2 to 4 weeks at a stable dose
So if we can get to 400 cases, you're going to be able to statistically look at second order of things
Additionally, if you notice signs of dehydration (such as dizziness, dry mouth, or dark urine), seek medical advice promptly
Osmotic diuresis from high glucose dehydration, loss of electrolytes (Na+, K+)
