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The research question: Can GH secretion be safely enhanced through peptides that work with natural regulatory mechanisms rather than replacing the hormone itself
Considering this feature, Asn240 is able to form hydrogen bonds with the conserved water molecule, the copper-coordinating His239, the backbone carbonyl group of Glu235 and the substrate (if it contains a functional group that is able to form H-bonds at its tail)
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The gradual increase gives the body time to adapt to the stronger receptor activation
Complexity of intervention (Intervention) Any pharmacological treatment is considered a complex intervention [30]
Useful when working with multiple peptides simultaneously
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