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And at the highest recommended doses for weight management, GLP-1s can deliver impressive results, with study participants losing more than 20% of their starting weight in just over a year, according to clinical trials
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Previous studies in rodents have also indicated that OB MCs are glucosensitive 32,33
Cancer & Metabolism , 2 (1), 6 Mulcahy Levy, J
The mechanisms behind GLP-1-related headaches are not fully understood, but likely involve changes in blood sugar levels (especially during early treatment when insulin sensitivity improves rapidly), dehydration from reduced fluid intake or GI losses, and the central nervous system effects of GLP-1 receptor activation, since GLP-1 receptors exist in the brain
however, for some people with obesity a pharmacotherapy treatment option like Saxenda may be needed to help them with chronic weight management," said Dr
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