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If a dose is missed, MHRA guidance recommends administering it as soon as possible within four days

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Appetite reduction typically begins within 1 to 2 weeks, with most men noticing significantly reduced hunger and quieter food noise by week 2 to 3

Perhaps for some people there are no AEs, but I think we require more long-term data with better outcomes than aBMD from DXA before we can be confident to conclude these drugs don't adversely impact bone

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Additionally, compounded medications can be made to include additional ingredients to reduce adverse effects and absorption, such as different peptides