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Most adverse effects associated with tirzepatide are mild to moderate in severity and tend to improve with continued use as the body adapts to the medication
A.et al (2019)
The 2023 American Association of Clinical Endocrinology (AACE) Comprehensive Type 2 Diabetes Algorithm recommends adding an SGLT2 inhibitor with outcomes data when a patient with atherosclerotic cardiovascular disease, CKD, or heart failure does not achieve glycemic targets on metformin alone, placing canagliflozin among the preferred second-line agents in those patient groups [21]
This suggests that the drastic inhibition of GLP-1 secretion by shutdown of the main pathway via the SSTRs-Gi axis is the primary cause of pasireotide-induced hyperglycemia
Research in animal models has shown that GLP-1 receptor activation dampens dopamine release in response to rewarding stimuli
Do Transdermal Herbal Patches Work for Weight Management
