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13 When comparing the active GLP-2R structure with the GLP-1-bound GLP-1R structure, 13 the extracellular end of TM1 in GLP-2R is extended by six additional residues, thereby bending toward GLP-2 with the formation of additional hydrogen bond and hydrophobic contacts

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Additionally, the Merck application does not disclose that a peptide-based melanocortin agonist may be administered by an intranasal route and a PDE-5 inhibitor administered by an oral route, or that the agents may be sequentially administered at timed intervals to obtain optimal results

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