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They also noticed higher reporting of vision impairment related to semaglutide use compared to other weight loss medications, including phentermine and orlistat

Variants in FTO (the fat-mass and obesity-associated gene), GLP1R (the GLP-1 receptor gene, the direct target of every GLP-1 compound), MC4R (a melanocortin receptor central to satiety), and TCF7L2 (a transcription factor tied to glucose homeostasis) describe the terrain any compound acts on

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However, if you have been waiting for an oral option, or if you are looking to transition off of injections, this is a fantastic new tool in our toolbox

Tirzepatide acts on both GIP and GLP-1 receptors, while semaglutide acts only on GLP-1 receptors

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