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People who are vegan or vegetarian are generally advised to take a vitamin B12 supplement rather than relying on fortified foods. In most cases, Romito says most people should seek to get their B vitamins from foods rather than from supplements

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Reduced NNMT in adipose tissue was associated with increased expression of polyamine flux genes and increased adipocyte energy expenditure connecting NNMT inhibition to "futile cycling" mechanisms that consume energy without productive metabolic output

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R.et al (2010)

Treating folate without checking B12 status