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Differential diagnosis of coma or sedation of unknown origin (to check if benzodiazepine involvement exists) --- Dosage (Adults): Initial dose: 0.2 mg IV over 15 seconds If no response, give 0.3 mg after 30 seconds May repeat 0.5 mg every 30 seconds up to a total of 3 mg (occasionally 5 mg if needed) --- Side Effects: Nausea and vomiting Dizziness Agitation or anxiety Headache Seizures (especially in patients dependent on benzodiazepines or co-ingesting tricyclic antidepressants) Arrhythmias (rare) --- Contraindications: Hypersensitivity to flumazenil Chronic benzodiazepine users (can trigger withdrawal and seizures) Patients with seizure disorders treated with benzodiazepines Mixed drug overdose (especially tricyclic antidepressants) --- Precautions: Continuous monitoring required for respiration and consciousness Risk of re-sedation after initial reversal due to flumazenils short half-life Use cautiously in hepatic impairment --- Storage: Store below 25C, protected from light
However, this still cannot be taken as fact
J Org Chem
Let stand or agitate briefly until the solution is perfectly clear
It may also be considered as part of broader longevity planning
Jaroszynska, N., Harding, P
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