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These alterations promote systemic low-grade inflammation through an imbalance between elevated pro-inflammatory cytokines (e.g., IL-6, TNF-) and anti-inflammatory mediators (e.g., IL-10) (267269)
Attenuating role of vitamin C on sperm toxicity induced by
It has been hypothesized that cardiac sympathetic tone is reduced in human obesity in response to volume overload (Messerli et al., 1983), in part induced also by sodium retention mediated by high renal SNS activity (DiBona, 1992)
Oral melanoma is diagnosed approximately a decade earlier in males than in females
53 Generally, the reported K m of PARP1 and CD38 for NAD + are lower than those of the sirtuins, suggesting that elevated activation of PARP1 or CD38 may limit endogenous SIRT activation by reducing NAD + content
Endocrinology 130 , 14451450 (1992)
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