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Between 2 and 1 h before the dark phase, rats were injected with either MTII or vehicle in randomized order using the same procedure as described previously (van den Heuvel et al., 2014b)
Some people find that half-step increases work better for their tolerance
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That model works well for many therapeutic areas
Since NASH is a largely asymptomatic disease, a drug with a burdensome side effect profile may not be acceptable
Common side effects include nausea (40-44%), diarrhea (29-33%), vomiting (24-25%), and constipation (21-24%)
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