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When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before
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While this differs from immunosuppression, individuals with complex autoimmune situations should consult specialists.
11, 12 While these studies cant prove the drugs prevented dementia, they strongly suggest that GLP-1 drugs provide meaningful protection against cognitive decline
Start your intake How Tirzepatide Affects Blood Pressure: The Clinical Evidence In the SURMOUNT trials, participants receiving tirzepatide showed consistent reductions in both systolic and diastolic blood pressure compared to placebo