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Because healthy, non-senescent cells do not rely on the FOXO4-p53 interaction for survival, FOXO4-DRI exhibits remarkable selectivity, clearing damaged cells while leaving healthy tissue unharmed
10.1016/j.jss.2004.06.016 9 BorodinaI.KennyL
Research Targets Extracellular-matrix signaling, angiogenesis-related pathways, nitric-oxide-associated signaling, gastrointestinal barrier models
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More importantly, the regeneration of glycocalyx through endothelial cell synthesis of glycosaminoglycans (GAGs) and shear stress-driven SDC recycling provides therapeutic prospects
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