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In Australia and new Zealand, the recommended dose is 500 to 1000 mg every four to six hours, not to exceed 4000 mg per day[1]
doi: 10.1016/j.cyto.2019.154884 43
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In the first approach, a series of 4-chloro-6,7,8-trimethoxyquinazoline ( 29 ) derivatives were synthesized and coupled with a variety of amines, which indicated that 7,8-dimethoxy functionalization on the quinazoline ring enhanced PDE1B inhibition, while the presence of a third 6-methoxy group was neither beneficial nor detrimental
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