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References Frohman LA, Downs TR, Chomczynski P

It also noted that as B12 deficiency increased, so too did insulin resistance

Reduced absorption of the B12-intrinsic factor complex can be caused by various gastrointestinal conditions including Crohns disease, celiac disease, intestinal bacterial overgrowth and intestinal parasites

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Sci Rep 12 , 12548 (2022)

The researchers theorized that glutathione depletion may play at least a partial causative role in reduced immune response in people with HIV, and that increasing systemic glutathione could improve immune system function in this group