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De la misma manera, se podra producir una disminucin de la ganancia ponderal al verse aumentado el metabolismo proteico para la produccin de energa, sobre todo en el RNPT, cuyos niveles de L-carnitina estn muy por debajo de lo habitual debido a una menor reserva tisular y a un dificultoso aporte de nutrientes

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In good agreement with the above-described processes, carnitine seems to be involved also in insulin sensitivity (Figure 1): it was observed that the muscle accumulation of fatty acyl-CoA derivatives or acyl metabolites inhibits both insulin signaling and glucose oxidation (Pietrocola et al., 2015

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This led to the creation of bremelanotide, also known as PT-141, a cyclic heptapeptide designed for selectivity

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Tesofensine is a triple monoamine reuptake inhibitor

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