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Besides improving glucose control, reducing body weight, and lowering arterial blood pressure (surrogate endpoints), the breakthroughs were the demonstration of a significant reduction in cardiovascular and renal events in patients with type 2 diabetes at high risk
The usual suspects are nausea, vomiting, diarrhea, and constipation
If these technologies mature to the point where a 39-amino acid peptide can be reliably delivered orally with clinically meaningful bioavailability, an actual oral tirzepatide pill becomes possible
LOINC: 81224-8)
12-week response check
The Role of the Incretin System in Glucose Homeostasis Incretin Biology Glucose homeostasis is dependent upon the complex interplay of multiple hormones including insulin, amylin, glucagon, and incretin hormones
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