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GLP-1-only therapies have an established track record, but adding GIP receptor activation amplifies those effects: appetite suppression is stronger, insulin sensitivity improves through two mechanisms at once, and blood sugar regulation benefits from both pathways working together
Always remove and safely dispose of the needle after each use to prevent contamination
Ensuring adequate protein intake, maintaining hydration, and preserving sleep quality help manage fatigue
If pancreatitis is suspected, Wegovy should be discontinued and appropriate diagnostic tests performed urgently Gallbladder problems : Rapid weight loss increases risk of gallstone formation, with cholelithiasis reported in approximately 1.6% of Wegovy users Intestinal obstruction/ileus : Cases have been reported in post-marketing surveillance, particularly in patients with pre-existing GI conditions Management strategies recommended by healthcare professionals include: Eating smaller, more frequent meals rather than large portions Avoiding high-fat, spicy, or heavily processed foods Staying well-hydrated, particularly if experiencing diarrhoea or vomiting, to prevent dehydration and potential acute kidney injury Not lying down immediately after eating to minimise reflux Ensuring adequate fibre intake to prevent constipation Taking the medication on the same day each week to maintain steady levels Most GI side effects improve over time as the body adjusts to the medication, typically becoming less troublesome after 4-8 weeks at each dose level
Wegovy is the only option of these three that has specifically been approved for use as a weight loss medication, only really differing from Ozempic by its recommended dosages
