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However, this same mechanism is directly responsible for many of the gastrointestinal side effects associated with the medication
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Similar to the findings of other studies in the STEP trial program 7,27 , exploratory outcomes showed that in the semaglutide group 80% of participants with prediabetes at baseline reverted to normoglycemia by the end of the trial (compared with 37% of those receiving placebo), while 99% of participants with normoglycemia at baseline maintained normoglycemia at the end of the trial (compared with 86% with placebo)
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If you are considering switching, the semaglutide to tirzepatide switching chart provides dose equivalency guidance
Long-term efficacy of metformin in overweight-obese PCOS: longitudinal follow-up of retrospective cohort
