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in vitroTwist1 contributes to the maintenance of some biological properties of dermal papilla cells by forming a complex with Tcf4 and -catenin

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Its maximal activity is about five times the rate of glucose consumption by the RBC, but it is subject to feedback (allosteric) inhibition by its product Glc-6-P

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Confirming the deficiency with a blood test is what makes that trade-off clear