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Preclinical studies have demonstrated that GLP-1 receptors are expressed in various ocular tissues, including the retina, and may play roles in neuroprotection, inflammation modulation, and vascular regulation

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Factors influencing symptom severity include: Rate of dose titration (slower escalation reduces symptoms) Meal size and composition (large, high-fat meals exacerbate symptoms) Individual variation in GLP-1 receptor sensitivity Concurrent medications affecting gut motility Patients should be counselled that these effects are pharmacologically expected and usually temporary, but persistent or severe symptoms warrant medical review to exclude complications such as pancreatitis, cholelithiasis, or cholecystitis

Proper hydration is important for overall health and can aid in weight loss