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These changes cause cellular dysfunction, cell cycle arrest and senescence with consequent secretion of pro-inflammatory and pro-fibrotic factors such as interleukin-1 (IL-1) and IL-6, TGF-1 and matrix metalloproteinases (MMPs) [12, 13]

In brief, animals were decapitated under deep anesthesia at the final phase of the experiment

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1.18 Diagnosis, clinical presentation and treatment The diagnosis of Hashimotos thyroiditis (HT) is made based on the clinical symptoms and biochemical findings of hypothyroidism