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Compared with participants who received a placebo, those treated with semaglutide showed slower aging patterns across multiple epigenetic clocks associated with inflammation and the health of several major organ systems, including the heart, brain, kidneys, liver, blood, and metabolic system
The divergence in event rates between treatment groups observed within 1 year across both randomized trials and equally in our analyses suggests that meaningful effects may emerge within a short time frame
Central and peripheral glucagon-like peptide-1 receptor signaling differentially regulate addictive behaviors
Funding DJD is supported by a Banting and Best Diabetes Centre Chair in Incretin Biology, the Sinai Health Novo Nordisk Foundation Fund in Regulatory Peptides, and CIHR Foundation grant 154321
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