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Archives of Biochemistry and Biophysics

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Suggest pre-op review 2 to 4 weeks prior for elective cases, discontinue or adjust according to agent half-life and GI effects, target glucose and insulin-bridge plans, document explicit handoffs, and reassert nutrition and wound risk post-op

A 2025 study found that tripling semaglutides dose to 7.2 mg led to roughly 19% weight loss over 72 weeks, compared to 16% at the standard dose, a meaningful gain, though with higher rates of side effects