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Know the typical studied dosing: many trials use 500 mg two to three times daily (often 1,0001,500 mg/day), usually split with meals

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Although these data are not available, it may also be hypothesized that the enhanced effects upon treatment with TDP-A-loaded or AB3-loaded targeted micelles are caused by the fact that the HDACis are targeted to the SSTR2-expressing tumor cells, resulting in enhanced receptor expression due to HDACi-mediated changes in the epigenetic machinery

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