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After reconstitution, keep refrigerated at 28C and use within 28 days

Trends Biochem Sci 33(1):28

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Altogether, pericytes, endothelial cells, astrocytes and neurons help form the BBB by directly communicating with each other and most importantly, pericyte loss is a central event in BBB damage and derangement that contributes to neurovascular dysfunction and neuronal injury, promoting also AD pathogenesis (Sengillo et al., 2013)

However, sirtuins cannot function without a steady supply of NAD+