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Effects of physicochemical properties and other factors on systemic nasal drug delivery

For instance, compounds like kojic acid show promising inhibitory effects but face limitations due to cytotoxicity or allergic reactions

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Presented for research literature review only Hosaki S et al

In two randomised controlled trials (RCT) in patients with coexisting ID anaemia and sub-clinical hypothyroidism, treatment with iron and L-T4 together was considerably more effective in improving iron status than was treatment with iron alone ( Reference Ravanbod, Asadipooya and Kalantarhormozi 60 , Reference Cinemre, Bilir and Gokosmanoglu 61 )

These symptoms are usually the end result of severe and excessive, acute or chronic stress