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These macrophage-derived metabolic signals synergistically increase lipid peroxidation through the ACSL4-dependent synthesis of PUFA-phospholipids, pushing cancer cells beyond their antioxidant capacity and into a state of ferroptosis
Anthocyanin production in yeast To highlight the practical relevance of our pathway elucidation, we set out to show that the catalytic activity of arGSTs is also required for anthocyanin biosynthesis in vivo in a eukaryotic cell and thus is key for production of anthocyanins ( 1 ) in microbial cell factories
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