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For quantification of sulfur-containing metabolites in cultured cancer cells and mouse serum, 10 l samples were extracted with 90 l of ice-cold extraction solvent (80% methanol and 20% H 2 O) containing isotope-labelled internal standards (36 M 13 C 2 15 N-GSH, 0.92 M 13 C 4 15 N 2 -GSSG and 10 M D 4 -cystine)

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In sum, these data support the development of novel ACMSD inhibitors to treat liver injury due to NASH and other etiologies

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1 Introduction Cerebrovascular disorders pose a significant challenge to human health, characterized by high incidence rates, disability, and mortality, thereby imposing a considerable burden on society and families (Zhang et al., 2024a)

Advances in biomarker discovery may further enable non-invasive diagnosis and personalized therapy