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Intravenous B12 therapy is used in certain cases

Call your health care provider immediately if you are experiencing any signs of an allergic reaction: skin rash, itching or hives, swelling of the face, lips, or tongue, blue tint to skin, chest tightness, pain, difficulty breathing, wheezing, dizziness, red, swollen painful area on the leg

Sometimes it is done to supplement the effects of a facelift

Some benefit from monthly sessions, while others may need them more regularly

Which suits a given study depends on the research design

I always try to get my B12 checked along with my regular lab work, since IBD is a risk factor for deficiency (SOURCE)