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These pathways converge to influence immune cell differentiation, trafficking, and effector function, ultimately conditioning the tumor immune microenvironment (Fig

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First, the heterogeneity between the model and the population is a key factor: preclinical studies are often conducted in animal models of a single disease (such as Diabetes Mellitus or senility), and the intervention dosage and duration are often optimized to highlight the muscle-preserving effect [60]