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MAPK/ERK Cascade and GILZ Homology Computational and molecular research identified structural homology between DSIP and GILZ (glucocorticoid-induced leucine zipper) a glucocorticoid-regulated protein that prevents Raf-1 activation and thereby inhibits ERK phosphorylation via the MAPK cascade
Several of these molecules deserve properly designed trials
most evidence is preclinical and observational
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Summarizing we provide a detailed characterization of the interaction of p53 with FOXO4 and FOXO4-DRI which is the basis for development of p53 inhibitors to treat diseases linked to cellular senescence such as cancers
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