However, tirzepatide has a longer track record and more extensive safety data
The GLP-1R is widely expressed in normal human tissues, including smooth muscle cells of arteries and arterioles of kidney and lung, -cells of the pancreas, myocytes of the sino-atrial node in the heart, Brunners gland in the duodenum and in myenteric plexus neurons in the human [2022], mouse [23], and non-human primate gut [24]
Vomiting, diarrhoea, constipation, abdominal pain, and dyspepsia are also well-documented adverse effects
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This is possible because these medications act through different mechanisms
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