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N Engl J Med (2015) 373(1):1122
No published controlled trial has studied combining tirzepatide and retatrutide in humans
Gastrointestinal AE with cagrisema were more than with semagutide or cagrilintide monotherapy, however the SAE and AE leading to medication discontinuation were minimal and similar between the groups [87, 90] A programme of phase 3 clinical trials (REDEFINE) assessing the safety and efficacy of cagrisema in people with obesity (NCT05567796, NCT05394519, NCT05813925) is currently ongoing
The testing includes accelerated stability studies (exposure to elevated temperatures to predict long-term behavior) and real-time stability studies (actual storage over the full shelf-life period)
Additionally, the safety and efficacy of tirzepatide in special populations, such as patients with renal impairment, require further investigation
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