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Initial studies in rats caused concerns over GLP-1 RAs causing thyroid cancer, but human studies are less clear on whether it is a concern.[ref] Decreased risk of substance abuse: A large 2026 study using data from the VA showed that GLP-1 RA drugs reduce the risk of developing a substance addiction (drugs, alcohol)

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This balanced potency profile distinguishes retatrutide from tirzepatide, which shows asymmetric affinity with GIPR binding closer to native potency and GLP-1R binding approximately five-fold lower than native

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