BPC-157 appears to stabilize neurotransmitter balance, particularly in pain processing pathways
Tirzepatide is an FDA-approved drug with completed Phase 3 obesity trials, while cagrilintide is investigational, with monotherapy data only through Phase 2 and its strongest results coming from the CagriSema combination
GLP-1 receptors are not found on skeletal muscle in humans, so any effects on muscle must be indirect
Liraglutide, in the LEADER trial, demonstrated a 13 percent reduction in cardiovascular death
But it is more than that, Ive discussed the cardiovascular and renal benefits of tirzepatide when the SURPASS-CVOT data was published (GIP: SURPASSing all expectations) But now we have trials for asthma, depression, bipolar, schizophrenia, substance use disorders, peripheral arterial disease, back pain, osteoarthritis and even more autoimmune diseases
When neuroanatomical associations of this behavioral effect were analyzed, intra-NTS Ex-4 (0.05 g per side) decreased alcohol-induced locomotor behavior, accumbal dopamine release, and memory consolidation of alcohol reward in mice, whereas a lower dose (0.025 g per side) was ineffective