FIGURE 1 Concerning dimerization, the GSTU dimer has an open V-shaped configuration with 2200 2 of the accessible surface that is buried at the interface, comparable with that of GSTOs (2000 2 ), but smaller than that of GSTFs (2700 2 ) and most other classes of GSTs (28003400 2 ) (Axarli et al., 2010)
When melanocytes are exposed to these phenolic compounds, they activate the UPR pathway and trigger the release of inflammatory cytokines from surrounding keratinocytes escalating immune activity against pigment cells
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doi: 10.1210/jcem.74.4.1532179 36 WiersingaWM