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168 Indeed, liver biopsies confirm that the prevalence of clinically significant fibrosis in MASLD and MASH patients is only 20.27% and 35.14%, respectively, 169 with lower proportions in patients with normal or lean body weight, 170 suggesting that antifibrotic treatment may not be necessary for a larger proportion of patients

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Hepatic and Metabolic Effects Excess caloric intake and insulin resistance drive hepatic lipid accumulation, producing metabolic-associated steatotic liver disease (MASLD, formerly NAFLD K76.0)

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