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For Kd estimation, a slow-exchange binding model was utilized, allowing for the evaluation of residue-specific isotherm curves by tracking changes in peak intensity during the titration

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CCDS1, caused by genetic variants in the SLC6A8 gene, is an X-linked inherited metabolic disorder with common clinical manifestations including mental retardation, severe speech disorders, epilepsy, movement disorders, and behavioral disorders

Manganese (As Manganese Sulfate)