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Paradoxically, GLP-1 agonists can cause diarrhoea as a side effect in some people despite generally slowing gut transit
Nonetheless, many clinical investigations are limited by short follow-up durations, small sample sizes, heterogeneous formulations, and reliance on surrogate endpoints, such as variations in bacterial diversity or inflammatory markers, rather than definitive clinical outcomes, thereby limiting the robustness of current conclusions (2, 4)
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However, the preclinical status means the full human side effect profile is not yet established
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